PHARMACOLOGICAL AND PHYSICO-CHEMICAL PROPERTIES OF COMPOSITIONS BASED ON BIOSURFACTANTS AND N-CONTAINING HETEROCYCLIC DERIVATIVES OF 1,4-NAPHTHOQUINONE

Composite preparations based on rhamnolipid biosurfactants and N-containing heterocyclic 1,4-naphthoquinone derivatives were obtained. The formation of the compositions was confirmed by UV spectroscopy, dynamic light scattering changes in surface tension comparison with original solutions. Physicochemical biological properties composite drugs have been studied. anticonvulsant effect assessed using pentylenetetrazole (PTZ) model. Doses PTZ for induction clonic-tonic seizures (DCTC) tonic extension (DTE) calculated relative to control. increasing permeability cell membranes compounds 1a-e evaluated indirectly studying activity. Compound (2-chloro-3-((3-(p-tolyl)-1H-pyrazol-5-yl)amino) naphthalene-1,4-dione) (1b) combination found a higher activity DCTC DTE averaged 239% 244%, respectively, which may indicate an improvement penetration compound when complex into as result, increased drug.